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J. Korean Ceram. Soc. > Volume 59(4); 2022 > Article
Journal of the Korean Ceramic Society 2022;59(4): 401-426.
doi: https://doi.org/10.1007/s43207-022-00217-w
Hybrid ceramics‑based cancer theranostics
Qingwen Guan1,2, Binbin He2, Jie Huang3, Helen H. Lu4, Min Wang1
1Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong, China
2Department of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen, China
3Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK
4Department of Biomedical Engineering, Columbia University, 1210 Amsterdam Avenue, New York, NY 10027, USA
Correspondence  Min Wang ,Email: memwang@hku.hk
Received: March 31, 2022; Revised: May 6, 2022   Accepted: May 31, 2022.  Published online: July 31, 2022.
ABSTRACT
Cancer is a major threat to human lives. Early detection and precisely targeted therapy/therapies for cancer is the most efective way to reduce the difculties (e.g., side efects, low survival rate, etc.) in treating cancer. To enable efective cancer detection and treatment, ceramic biomaterials have been intensively and extensively investigated owing to their good biocompatibility, high bioactivity, suitable biodegradability and other distinctive properties that are required for medical devices in oncology. Through hybridization with other materials and loading of imaging agents and therapeutic agents, nanobioceramics can form multifunctional nanodevices to simultaneously provide diagnostic and therapeutic functions for cancer patients, and these nanodevices are known as hybrid ceramics-based cancer theranostics. In this review, the recent developments of hybrid ceramics-based cancer theranostics, which include the key aspects such as their preparation, biological evaluation and applications, are summarized and discussed. The challenges and future perspectives for the clinical translation of hybrid ceramics-based cancer theranostics are also discussed. It is believed that the potential of hybrid ceramic nanoparticles as cancer theranostics is high and that the future of these theranostics is bright despite the difculties along the way for their clinical translation.
Key words: Cancer · Detection · Therapy · Theranostics · Multifunctional · Bioceramics · Calcium phosphate · Silica · Bioactive glass · Clinical
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