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J. Korean Ceram. Soc. > Volume 57(5); 2020 > Article
Journal of the Korean Ceramic Society 2020;57(5): 495-502.
doi: https://doi.org/10.1007/s43207-020-00048-7
Electrically stimulated hydroxyapatite–barium titanate composites demonstrate immunocompatibility in vitro
Subhasmita Swain1,2, Rabindra Nath Padhy1, Tapash Ranjan Rautray2
1Central Research Laboratory, IMS and SUM Hospital, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha 751003, India
2Biomaterials and Tissue Regeneration Laboratory, Centre of Excellence in TM Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Khandagiri Square, Bhubaneswar, Odisha 751030, India
Correspondence  Tapash Ranjan Rautray ,Email: tapash.rautray@gmail.com
Received: December 17, 2019; Revised: February 28, 2020   Accepted: March 3, 2020.  Published online: September 30, 2020.
ABSTRACT
For fabricating the filler materials for tissue re-growth, the primary concern should be focused on the immunocompatibility of the material. Lymphocyte T-cells and macrophages activate each other and induce immune suppressive effects. Polarized hydroxyapatite–barium titanate composite surfaces showed comparatively less macrophage activity than unpolarized surfaces. Lymphocytes isolated from human umbilical cord blood were cultured separately on both polarized and unpolarized samples. The macrophage with nitric oxide and myeloperoxidase showed less activity on polarized composite surfaces as compared to lipopolysaccharide of stimulated cells from which it can be inferred that the polarized composites showed immunocompatibility for which these materials can be used a preferred material in tissue engineering applications.
Key words: Hydroxyapatite · Barium titanate · Polarization · Immunocompatibility
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