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J. Korean Ceram. Soc. > Volume 57(4); 2020 > Article
Journal of the Korean Ceramic Society 2020;57(4): 392-400.
doi: https://doi.org/10.1007/s43207-020-00028-x
Strontium‑substituted biphasic calcium phosphate scaffold for orthopedic applications
Bijayinee Mohapatra, Tapash R. Rautray
Biomaterials and Tissue Regeneration Laboratory, Centre of Excellence in Theoretical and Mathematical Sciences, Siksha ‘O’ Anusandhan University, Khandagiri Square, Bhubaneswar, Odisha 751030, India
Correspondence  Tapash R. Rautray ,Email: tapash.rautray@gmail.com
Received: November 21, 2019; Revised: January 2, 2020   Accepted: January 6, 2020.  Published online: April 30, 2020.
ABSTRACT
Strontium ion-substituted calcium phosphate-based ceramic scaffolds enhance osteogenesis. The objective of the present study was to optimize the strontium hydroxyapatite (Sr-HA) and beta tricalcium phosphate (β-TCP) ratio in the fabricated scaffolds to enhance their mechanical strength and bioactivity with controlled biodegradability. Porous polyurethane sponge scaffolds containing Sr-HA and β-TCP in varying concentration were developed by dipping 3D sponge pieces into a slurry containing 10% gelatin, proper concentration of biphasic calcium phosphate (BCP) and 3% poly vinyl alcohol. Four different samples [Sr-BCP, Sr-BCP (20/80), Sr-BCP (30/70), Sr-BCP (40/60)] were prepared and were characterized for biodegradability, water uptake capability and cytotoxicity using various techniques. Pure, crystalline, cytocompatible Sr-BCP Scaffolds possessing both micropores and macropores with porosity greater than 80% and water uptake capability above 100% were obtained. Thus, the effective substitution of Sr-HA and β-TCP in varying proportion makes the composite scaffold a distinctive material of bone tissue engineering.
Key words: BCP · β-TCP · Strontium hydroxyapatite · Composite scaffolds · Biocompatibility
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