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J. Korean Ceram. Soc. > Volume 57(2); 2020 > Article
Journal of the Korean Ceramic Society 2020;57(2): 175-183.
doi: https://doi.org/10.1007/s43207-020-00018-z
Silver‑incorporated hydroxyapatite–albumin microspheres with bactericidal effects
Saswati Mishra, Tapash R. Rautray
Biomaterials and Tissue Regeneration Laboratory, Centre of Excellence in Theoretical and Mathematical Sciences, Siksha ‘O’ Anusandhan University, Khandagiri Square, Bhubaneswar, Odisha 751030, India
Correspondence  Tapash R. Rautray ,Email: tapash.rautray@gmail.com
Received: November 9, 2019; Revised: November 30, 2019   Accepted: December 6, 2019.  Published online: February 29, 2020.
ABSTRACT
Bacterial adhesion on HA-coated implant is a serious problem that often leads to bone infection such as osteomyelitis on implant sites. Gram-positive bacteria such as Staphylococcus aureus are responsible for such infection-forming biofilm on implant surfaces. Therefore, inclusion of antimicrobial agents especially inorganic ions such as silver has gained vogue due to their strong antibacterial effects. This study reports the fabrication of porous Ag–albumin–HA microspheres by waterin- oil emulsion technique. Varied proportions of porogen with HA ensured enhanced pores in the fabricated microsphere. Further, SEM analysis revealed the presence of microspheres in the range ~ 50–900 μm with interconnected pores ranging between ~ 10 and 50 μm. Antibacterial efficacy of the Ag–HA hybrid disrupting the biofilm was observed. The as-formed microspheres having interconnected pore channels are envisaged to show vascularization as well as fulfilling goals of ideal bone filler ensuring biocompatibility and reducing long-term cytotoxicity at implant site.
Key words: Hydroxyapatite · Albumin · Silver chloride · Bactericidal effect
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