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J. Korean Ceram. Soc. > Epub ahead of print

doi: https://doi.org/10.4191/kcers.2019.56.1.06    [Epub ahead of print]
Setting Behavior and Drug Release from Brushite Bone Cement prepared with Granulated Hydroxyapatite and β-Tricalcium Phosphate
Yeong-Jun Son, In-Cheol Lee, Hyun-Ho Jo, Tai-Joo Chung, Kyung-Sik Oh
School of Advanced Materials Engineering, The Center of Biomedical Materials and Biotechnology, Andong National University, Andong 36729, Korea
Correspondence  Kyung-Sik Oh ,Tel: +82-54-820-5783, Fax: +82-54-820-6211, Email: ksoh@anu.ac.kr
Received: October 3, 2018;  Accepted: December 10, 2018.  Published online: January 10, 2019.
Calcium phosphate bone cement was prepared to contain antibiotics for release after setting using granulated β-tricalcium phosphate (β-TCP) and hydroxyapatite (HA). Gentamicin sulfate (GS) solution was infiltrated within the interconnected pores of the granule to avoid affecting the setting reaction and for protection of GS during the setting. Consequently, the setting time and the temperature increase were not affected, regardless of the loading of GS. The release of the GS from the cement was estimated by measuring the concentration at regular intervals from the cement dipped solution. The β-TCP granule loaded with GS exhibited the saturation of accumulative concentration at 16 h. In contrast, the HA granule with GS exhibited steady increase in accumulative concentration of over 10 µg/ml at 144 h. Thus, the granulated cement could release the GS greater than the minimum inhibitory concentration of staphylococcus during the prescription peroid of the oral antibiotics.
Key words: Bone cement, Granule, Gentamicin, Hydroxyapatite, β -TCP
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