| 노즐 낙하법으로 제조한 히알루론산 다공성 마이크로비드의 가교온도에 따른 팽윤특성 |
| 김영훈, 이인규, 김진태1, 박주현1, 이득용1 |
항공대학교 재료공학과
1대림대학교 재료정보학과 |
| Dependence of Crosslinking Temperature on Swelling Behavior of Hyaluronic Acid Porous Microbeads Synthesized by a Modified Spray Method |
| Young-Hun Kim, In-Kyu Lee, Jin-Tae Kim1, Ju-Hyun Park1, Deuk Yong Lee1 |
Department of Materials Engineering, Korea Aerospace University
1Department of Materials Engineering, Daelim University |
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| ABSTRACT |
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Hyaluronic acid (HA) microbeads were synthesized by dropping 0.5 wt% of sodium hyaluronate dissolved in NaOH into 0.2 vol% of divinyl sulfone dissolved in 2-methyl-1propanol at a speed of 0.005 ml/min. HA microbeads were collected from a divinyl sulfone crosslinker solution stirred at 200 to 400 rpm for 5 h at temperatures from room temperature to $60^{circ}C$ at intervals of $10^{circ}C$. The crosslinked microbeads were then cleaned thoroughly using distilled water and ethanol. SEM results revealed that the microbeads were white-colored spheres. The 3-D porous network structure of the microbeads became dense with an increase in the crosslinking temperature; however, no dependence of the crosslinking temperature on the microbead size was detected. The extent of swelling decreased from 970% to 670% with an increase in the crosslinking temperature from room temperature to $60^{circ}C$, most likely due to the increase in the degree of crosslinking. |
| Key words:
Hyaluronic acid(HA), Microbeads, Crosslinking temperature, Swelling |
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