Study on the Biocompatibility of Hydroxyapatite Bioceramics : (II) Behavior in Simulated Body Fluid and Biocompatibility

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J. Korean Ceram. Soc. > Volume 27(6); 1990 > Article

Journal of the Korean Ceramic Society 1990;27(6): 721.

Hydroxyapatite Bioceramics의 생체 친화성에 관한 연구 : (II) 인공 체액에서의 거동 및 생체 친화성

김양수, 고형열¹, 송종택², 최상흘¹

단국대학교 화학과
¹한양대학교 무기재료공학과
²단국대학교 재료공학과

Study on the Biocompatibility of Hydroxyapatite Bioceramics : (II) Behavior in Simulated Body Fluid and Biocompatibility

ABSTRACT

Hydroxyapatite powders were synthesized with Ca/P=1.67 and pH=11 by precipitaton method, after characterization of these specimen, behavior in Ringer's solution and biocompatibility of hydroxyapatite, such as cytotoxity test and implantation test, were investigated. The hydroxyapatite ceramics had structural stability in Ringer's solution, and hydroxyapatite ceramics did not prevent cell growing and exhibit any cytotoxic effects. In implantation of hydroxyapatite ceramics into muscle under abdome of guinea pig, hydroxyapatite ceramics did not show any symptom of rejection for cellular texture.