| Strontium‑substituted biphasic calcium phosphate scaffold for orthopedic applications |
Bijayinee Mohapatra, Tapash R. Rautray
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| Biomaterials and Tissue Regeneration Laboratory, Centre of Excellence in Theoretical and Mathematical Sciences, Siksha ‘O’ Anusandhan University, Khandagiri Square, Bhubaneswar, Odisha 751030, India |
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Received: November 21, 2019; Revised: January 2, 2020 Accepted: January 6, 2020. Published online: April 30, 2020. |
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| ABSTRACT |
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Strontium ion-substituted calcium phosphate-based ceramic scaffolds enhance osteogenesis. The objective of the present study was to optimize the strontium hydroxyapatite (Sr-HA) and beta tricalcium phosphate (β-TCP) ratio in the fabricated scaffolds to enhance their mechanical strength and bioactivity with controlled biodegradability. Porous polyurethane sponge scaffolds containing Sr-HA and β-TCP in varying concentration were developed by dipping 3D sponge pieces into a slurry containing 10% gelatin, proper concentration of biphasic calcium phosphate (BCP) and 3% poly vinyl alcohol. Four different samples [Sr-BCP, Sr-BCP (20/80), Sr-BCP (30/70), Sr-BCP (40/60)] were prepared and were characterized for biodegradability, water uptake capability and cytotoxicity using various techniques. Pure, crystalline, cytocompatible Sr-BCP Scaffolds possessing both micropores and macropores with porosity greater than 80% and water uptake capability above 100% were obtained. Thus, the effective substitution of Sr-HA and β-TCP in varying proportion makes the composite scaffold a distinctive material of bone tissue engineering. |
| Key words:
BCP · β-TCP · Strontium hydroxyapatite · Composite scaffolds · Biocompatibility |
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